The Schmeing Lab
Research in the Schmeing Lab
The Schmeing Lab focuses on understanding how large, natural biosynthetic enzymes create their remarkable and valuable products. Two key enzyme systems under investigation are nonribosomal peptide synthetases, NRPSs, which synthesize important compounds such as the antibiotic daptomycin, the anti-cancer drug actinomycin, and the immunosuppressant cyclosporin, and cyanophycin synthetase, which produces a versatile and sustainable green polymer.
Using cutting-edge techniques including cryo-electron microscopy, cryo-EM, X-ray crystallography, chemical biology, and biochemical approaches, our lab visualizes and deciphers the complex mechanisms of these enzymes. This research not only provides a deeper understanding of these natural nano-factories but also enables bioengineering advancements for the synthesis of novel therapeutics and environmentally friendly chemicals.
In addition to scientific discoveries, we bring these systems to life through molecular animations that illustrate intricate biosynthetic processes. These animations have become a hallmark of our presentations at conferences and seminars, often paired with dynamic music to engage audiences. If you've seen a visual explanation of an NRPS, cyanophycin synthetase, or ribosome in action, it was likely our work!
Who We Are
The Schmeing Lab is a dynamic and collaborative team that includes M.Sc. students, Ph.D. students, postdoctoral fellows, and a research associate, supported by undergraduate researchers who join through independent study courses or internships. Our team has welcomed members from over 20 countries across five continents, reflecting the global nature of science and creating a rich multicultural environment.
This diversity brings fresh perspectives to our work, fostering creativity, innovation, and a supportive atmosphere. We not only share scientific ideas but also take the time to learn from each other's cultures, making the lab a uniquely enriching and collaborative space.
A Broader Network
The Schmeing Lab is part of the Centre for Structural Biology, where Martin serves as Director. This affiliation provides access to state-of-the-art facilities, interdisciplinary collaboration opportunities, technical training, and professional development workshops. The Centre also hosts research-in-progress talks (with free pizza!) and supports travel grants, offering a comprehensive ecosystem for growth and success.
Within the Biochemistry Department, we are surrounded by researchers tackling diverse challenges in molecular biology, creating exciting opportunities for collaboration. These interactions often lead to new ideas, shared expertise, and impactful publications.
Where We Work and Play
Our lab is housed in the Bellini Life Sciences Building, situated in the heart of downtown Montreal. This prime location combines the vibrant energy of a cosmopolitan city with the serene beauty of Mount Royal, a leafy park ideal for jogging, cross-country skiing, or simply enjoying nature between experiments.
But we don’t just work hard—we also know how to have fun. Some of our cherished traditions include:
Annual Fun Weekend: A three-day canoe-camping trip in the Canadian wilderness, where we bond as a team and search for the elusive "Batmoose," our lab's spirit animal.
Celebratory Cork Drops: Marking the publication of new papers by dropping corks in a unique tradition.
Lab Game Days: Using games like brainball to creatively name new equipment and hosting fun, team-building activities.
Weekly Rituals: Enjoying Montreal's famous bagels every Friday and well-earned coffee breaks to recharge.
Holiday Dinner: A festive evening featuring delicious food and the competitive Danish dice gift exchange.
Our commitment to fostering a positive, collaborative environment extends beyond the lab bench, ensuring that everyone feels supported and inspired to achieve their best.
To learn more about our research, team, and activities, visit our lab website
